What causes peripheral neuropathy flare-ups?

Flare-ups can occur without a cause or stimulus, but in most cases the flare-up is caused by a known cause. Be sure to take the pain medication prescribed by the doctor as prescribed and at the same time each day. Exercise or an increase in daily activity from the previous day may cause the aggravation of symptoms in the day following. Walking on hard surfaces or using shoes that do not provide enough support can aggravate symptoms associated with a flare-up. 

Physical and emotional stress heightens the nervous system, which leads to pain arising in the feet thereafter. A daily life with high levels of stress may lead to an increase in frequency of flare-ups. Foot soaks can also be done to help reduce stress and pain associated with diabetic neuropathy, and may help you sleep better at night. 

In some cases, vitamin deficiencies can aggravate symptoms of pain. Vitamin B is essential for nerve health and at low levels in the body can cause nerve damage.